Table 2. Multivariable analyses on the repeated measures of endocervical interleukin (IL)-2 and IL-12 concentrations in response to Chlamydia trachomatis infectiona.
| IL-2 (n = 1660c) | IL-12 (n = 1680c) | |||
|---|---|---|---|---|
| Covariates | βd | P-value | βd | P-value |
| Race (African American versus other) | 0·057 | 0·071 | 0·024 | –b |
| Age (< 17 versus ≥ 17) | 0·006 | –b | 0·002 | –b |
| Sexual partner (≥ 2 versus < 2) | 0·007 | –b | − 0·043 | –b |
| CD4+ T cell count (< 400 versus ≥ 400 cells/µl) | 0·037 | –b | − 0·008 | –b |
| Oral contraceptive in past 3 months (yes versus no) | 0·102 | 0·0002 | 0·206 | 0·002 |
| HIV-1 infection (yes versus no) | 0·001 | –b | − 0·164 | 0·044 |
| Cervical HPV infection (yes versus no) | 0·019 | –b | 0·026 | –b |
| Bacterial vaginosis (yes versus no) | 0·093 | 0·001 | 0·034 | –b |
| Trichomonas infection (yes versus no) | − 0·018 | –b | − 0·255 | 0·079 |
| Cervical gonorrhoea infection (yes versus no) | − 0·155 | 0·03 | 0·524 | 0·002 |
| Cervical chlamydial infection (yes versus no) | − 0·169 | 0·0002 | 0·422 | < 0·0001 |
a
The interleukin (IL)-2 and IL-12 concentrations are log10 transformed in the analyses here.
b
P values = 0·20 are omitted and shown as ‘-’.
c
Number of measures available.
d
Slopes of cytokines in response to chlamydial infection.