Table 2. Classically activated Mφ generation in thermally injured mice treated with Ge-132.
Mφ from thermally injured SCIDbg mice treated with | IL-10 | IL-12 | CCL3 | CCL17 |
---|---|---|---|---|
Saline | 604 ± 130 | < 20 | < 18 | 527 ± 104 |
Ge-132 | < 8* | 616 ± 74* | 2136 ± 277** | < 16* |
Thermally injured SCIDbg mice were treated with or without Ge-132 and infected with MRSA. Mφ from these mice 1 day after infection were cultured for 24 h. Culture fluids harvested 24 h after cultivation were assayed for cytokines and chemokines using ELISA. Data are expressed as mean (pg/ml) ± SD and representative of 3 experiments.
P < 0·01
P < 0·001 compared with thermally injured SCIDbg mice treated with saline.