Table 1. Summary of the most relevant interactions of herpes simplex virus (HSV) with dendritic cells (DC). The most important effects of HSV on DC are summarized.

HSV and DC interaction	In vitro	In vivo	Reference
Down-regulation of co-stimulatoy molecules and MHC molecules	x		[4]
Formation of ICP47-TAP complex which blocks the MHC I translocation		x	[1,5–7]
Reduction of the expression of the invariant chain	x		[13]
Reduced production of interleukin-12 after lipopolysaccharide stimulation	x		[8]
Loss of CD83 surface expression	x		[10,12]
Anti-apoptotic mechanisms	x		[17]
Pro-apoptotic mechanisms	x		[18]
Down-regulation of chemokine receptors and lower migration	x		[19]