The time course of production of specific antibody isotypes: IgM, IgG1, IgG2a, and IgG2b. The presence of each specific antibody isotype was analysed by indirect ELISA. (a) IgM, (b) IgG1, (c) IgG2a, and (d) IgG2b. • 20-L3 group; ○ the 5-L3 group. The arrows indicate times of infection. Each rat was infected with either 20- or 5-L3. SEs are shown as bars.