Table 2.
Polymorphisms of Toll-like receptors (TLR) 2 and 4 genes in osteomyelitis (OM) patients and controls.
| Gene | Genotype frequencies | OM | Controls | Pearson χ2 | Odds ratio (95% CI) | P-value | Allele frequencies | OM | Controls | Pearson χ2 | Odds ratio (95% CI) | P-value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TLR4 Asp(299)Gly | ||||||||||||
| No. of patients. (%) | 80 (100·0) | 155 (100·0) | ||||||||||
| GG | 3 (3·8) | 0 (0·0) | 5·86 | NA | 0·038 | A | 18 (0·11) | 20 (0·07) | 3·11 | 1·81 (0·88–3·71) | 0·08 | |
| AG | 12 (15·0) | 20 (12·9) | ||||||||||
| AA | 65 (81·2) | 135 (87·1) | G | 142 (0·89) | 290 (0·93) | |||||||
| TLR4 Thr(399)Ile | ||||||||||||
| No. of patients (%) | 80 (100·0) | 155 (100·0) | ||||||||||
| TT | 3 (3·5) | 0 (0·0) | 5·86 | NA | 0·038 | T | 16 (0·1) | 22 (0·08) | 1·19 | 1·45 (0·7–2·99) | 0·27 | |
| CT | 10 (12·04) | 22 (14·45) | ||||||||||
| CC | 67 (84·3) | 133 (85·44) | C | 144 (0·9) | 288 (0·92) | |||||||
| TLR2 Arg(753)Gln | ||||||||||||
| No. of patients (%) | 80 (100·0) | 155 (100·0) | ||||||||||
| AA | 0 (0) | 0 (0) | NA | NA | NA | A | 2 (0·02) | 3 (0·01) | 0·08 | 1·3 (0·15–9·61) | 0·78 | |
| GA | 2 (2·4) | 3 (1·9) | ||||||||||
| GG | 78 (97·6) | 152 (98·1) | G | 158 (0·98) | 307 (0·99) |
NA, not applicable; OM, osteomyelitis; 95% CI, 95% confidence intervals.