Table 3.
Clinical characteristics of the osteomyelitis (OM) patients, carriers of the different TLR4 Asp(299)Gly genotypes, and of the blood donor controls.
| TLR4 GG (n = 3) | TLR4 AG (n = 12) | TLR4 GG + AG (n = 15) | TLR4 AA (n = 65) | Controls (n = 155) | |
|---|---|---|---|---|---|
| Female sex/total cases (%) | 3/3 (100)* | 1/12 (8·3) | 4/15 (26·7) | 22/65 (33·8) | 55/155 (35·5) |
| Mean age (years) | 49·7 ± 15·6 | 59·8 ± 12·4 | 57·5 ± 13·2 | 52·5 ± 17·8 | 51·8 ± 20·1 |
| Acute OM (%) | 0/3 (0) | 1/12 (8·3) | 1/15 (6·7)† | 23/65 (35·4) | NA |
| Hematogenous source of infection (%) | 1/3 (33·3) | 5/12 (41·7)‡ | 6/15 (40·0)§ | 7/65 (10·8) | NA |
| Gram negative OM (%) | 2/3 (66·6) | 7/12 (63·6)¶ | 9/15 (60·0)** | 14/65 (21·5) | NA |
OM, osteomyelitis; NA, not applicable.
P = 0·045 by the Fisher's exact test while comparing the female frequency between OM patients carriers of the GG genotype versus AA genotype.
χ2 = 3·52; OR (95%CI) = 0·13 (0·01–1·06); P = 0·031 by the Fisher's exact test while comparing the frequency of acute OM between patients who were carriers of the GG + AG genotypes versus AA genotype.
χ2 = 5·19; OR (95%CI) = 5·92 (1·21–29·65); P = 0·017 by the Fisher's exact test while comparing the frequency of haematogenous OM between patients who were carriers of the AG genotype versus AA genotype.
χ2 = 5·65; OR (95%CI) = 5·52 (1·27–24·58); P = 0·013 by the Fisher's exact test while comparing the frequency of haematogenous OM between patients who were carriers of the GG + AG genotypes versus AA genotype.
χ2 = 5·18; OR (95%CI) = 5·1 (1·27–22·51); P = 0·025 by the Fisher's exact test while comparing the frequency of Gram negative OM between patients who were carriers of the AG genotype versus AA genotype.
χ2 = 7·02; OR (95%CI) = 5·46 (1·45–21·34); P = 0·0086 by the Fisher's exact test while comparing the frequency of Gram negative OM between patients who were carriers of the GG + AG genotypes versus AA genotype.