Fig 2.

Growth of reporter Mycobacterium tuberculosis H37Rv in whole blood cultures after 48 and 96 h. Whole blood cultures of bacille Calmette–Guérin-vaccinated tuberculin-positive healthy subjects (n = 23) were infected with reporter M. tuberculosis H37Rv and examined for growth at 48 and 96 h of infection by measuring relative light units (RLU)/ml as described in Materials and methods. Paired values from the individual subjects are connected. Growth is expressed as growth ratio (GR) = (RLU of reporter M. tuberculosis H37Rv at 48 h (or 96 h)/RLU of reporter M. tuberculosis H37Rv at 0 time. Each point represents the mean of triplicate determinations; paired values from the individual subjects are connected. At 48 h, the median of GR = 1·33, range = 0·29–6·46; at 96 h, median of GR = 0·39, range = 0·002–4·4 (P < 0·029 by paired t-test).