Table 1.
Concentration of cytokines detected in the supernatants of whole blood cultures of healthy subjects following infection with reporter Mycobacterium tuberculosis H37Rv.
| Median cytokine concentration (range) in the culture supernatants at | |||
|---|---|---|---|
| 0 h | 48 h | 96 h | |
| TNF-α (pg/ml) | < 15·6 (< 15·6–59) | 763 (< 15·6–5626)a | 269 (< 15·6–4545)b,c |
| IFN-γ (IU/ml) | 2·3 (< 0·39–16) | 2·88 (< 0·39–18) | 3·9 (< 0·39–99) |
| IL-12 (pg/ml) | 41 (< 16–865) | 38 (< 16–1355) | 74 (< 16–1251) |
| IL-10 (pg/ml) | < 16 (< 16–2376) | 9·3 (< 16–2612) | < 16 (< 16–1767) |
a
P < 0·001, compared to the value at 0 h
b
P < 0·0017, compared to the value at 0 h
c
P < 0·001, compared to the value at 48 h. IFN: interferon; IL: interleukin; TNF: tumour necrosis factor.