Table 6.
The percentage of T cells producing intracellular cytokines in bronchoalveolar lavage (BAL) and bronchial brushing (BB) of the lung transplant group (mean ± s.d.). There was a significant decrease in the percentage of CD4+ and a significant increase in the percentage of CD8+ T cells in BB. There was a significant increase in the percentage of CD4 and CD8+ T cells producing interferon (IFN)-γ and CD8 T cells producing tumour necrosis factor (TNF)-α, and a significant decrease in the percentage of CD4+ and CD8+ T cells producing interleukin (IL)-4 and transforming growth factor (TGF)-β in BB compared to BAL.
| CD3 | IFN-γ | IL-2 | IL-4 | TGF | TNF-α | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CD4 | CD8 | CD4 | CD8 | CD4 | CD8 | CD4 | CD8 | CD4 | CD8 | CD4 | CD8 | |
| BAL | 50 ± 11 | 50 ± 11 | 10 ± 9 | 17 ± 15 | 5 ± 5 | 3 ± 3 | 5 ± 4 | 5 ± 4 | 4·6 ± 2 | 5 ± 2·1 | 19 ± 10 | 12 ± 11 |
| BB | 37 ± 11 | 63 ± 11 | 17 ± 7 | 40 ± 13 | 8 ± 4 | 3 ± 1·6 | 1·2 ± 1 | 2·3 ± 2 | 2 ± 0·9 | 1·7 ± 1 | 18 ± 7 | 30 ± 11 |
| P | 0·006 | 0·006 | 0·029 | 0·001 | 0·100 | 0·210 | 0·002 | 0·025 | 0·035 | 0·028 | 0·657 | 0·002 |