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Scatter-plot of the amount of membrane attack complex (MAC)-circulating immune complexes (CIC), soluble MAC (SMAC), clusterin (clust)–CIC and clust–SMAC. Monoclonal antibody aE11 directed to a neoepitope on polymerized C9 was used as capture reagent in an enzyme-linked immunosorbent assay (ELISA)-based assay to measure SMAC. A strong correlation was observed between the levels of the clusterin present on SMAC and MAC–CIC.
