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Binding to the AE9D6-defined epitope is correlated inversely with age at onset. Binding of type 1 diabetes (T1D) patient sera to [125]I insulin in the presence of recombinant Fab (rFab) AE9D6 was correlated to age at onset (in years). Binding of sera to [125]I insulin in the presence of rFab AE9D6 is presented as percentage in relation to uncompeted binding of sera to [125]I insulin (set as 100%). A linear regression curve is indicated.
