FIGURE 40.

Persistent inhibition of subretinal neovascularization (SRN). After rechallenge by repeat laser to induce SRN again, the fluorescein angiogram data at the 10-month period revealed significant difference between 10× viral K1-5 treated eyes and contralateral controls (P = .0006) and subretinal injected control (GFP and saline) eyes (P = .0017). A total of 16 primate eyes were compared: three control subretinal injections, two saline (black underline) and one lentiviral GFP (green underline); five lentiviral K1-5 subretinal injections (two 1× and three 10× concentration); and eight noninjected contralateral controls.