Table 1.
Summary of cell based therapy in the inner ear
| Author and experimental aim | Cell type transplanted | Animal model (recipient) | Deafened (✓ or X) | Maximum cell survival time (weeks) | Transplantation site | |
|---|---|---|---|---|---|---|
| 1. | Hair cell regeneration | |||||
| Ito et al., 2001 | Rat adult neural stem cell | Neonatal rat (P0–P2) | X | 4 | Cochlear cavity | |
| Tateya et al., 2003 | Mouse fetal neural stem cell | Mouse | ✓ | 3.3 | Cochlea (turn 2) | |
| XHildebrand et al., 2005 | Mouse embryonic stem cells | Guinea pig | ✓ | 9 | Scala media | |
| 2. | Trophic support to SGNs | |||||
| Iguchi et al., 2003 | Mouse fetal neural stem cell | Mouse | X | 4 | Semicircular canal (adjacent to cochlea) | |
| 3. | Replacement of SGNs | |||||
| Olivius et al., 2003 | Guinea pig fetal dorsal root ganglion explant | Guinea pig | ✓ | 3 | Scala tympani | |
| XHu et al., 2003 | Mouse fetal dorsal root ganglion explant | Rat | ✓ | 3 | Scala tympani | |
| Naito et al., 2004 | Chinchilla bone marrow stromal cell | Chinchilla | ✓ | 3 | Auditory nerve | |
| XRegala et al., 2005 | Mouse fetal dorsal root ganglion explant, Mouse embryonic stem cells, Mouse adult neural stem cells | Guinea pig Rat | X | 4 | Auditory nerve | |
| XHu et al., 2005 A | Mouse adult neural stem cells | Guinea pig | ✓, X | 4 | Scala tympani | |
| XHu et al., 2005 B | Mouse fetal dorsal root ganglion explant, Mouse embryonic stem cells | Guinea pig | ✓ | 4 | Scala tympani | |
| XColeman et al., 2005 | Mouse embryonic stem cell | Guinea pig | ✓ | 4 | Scala tympani |
X
indicates xenotransplant.
SGN: spiral ganglion neuron.