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. Author manuscript; available in PMC: 2008 Jan 12.
Published in final edited form as: Mol Cell. 2007 Jan 12;25(1):113–126. doi: 10.1016/j.molcel.2006.11.028

Figure 7. Global and Transcript-specific Translational Silencing by Targeting eIF4G.

Figure 7

(A) Global inhibition of translation by targeting eIF4G. Virus infection, apoptosis, and cell stress target eIF4G by different mechanisms.

(B) L13a targets eIF4G for transcript-specific inhibition of translation. L13a in the 3′ UTR-bound GAIT complex targets eIF4G without cleavage of eIF4G or disruption of cap-binding eIF4F complex. Binding of phospho-L13a to eIF3 binding site of eIF4G blocks interaction of 43S ribosomal complex and represses translation initiation.