Table 2.
Clinical parameters (mean ± s.d.) over time.
| Clinical parameter | n | Baseline | 1 month | 3 months | 6 months |
|---|---|---|---|---|---|
| MRSS | 18 | 16·00 (9·32) | 16·67 (8·95) | 17·00 (8·56) | 16·39 (7·93) |
| FVC | 18 | 3·17 (0·98) | n.a. | 3·11 (0·97)* | 3·08 (0·98)* |
| Adjusted DLCO2 | 171 | 15·57 (4·35) | n.a. | 16·25 (5·77) | 16·08 (5·18) |
| MHAQ | 173 | 0·53 (0·51) | 0·44 (0·48) | 0·46 (0·35) | 0·40 (0·33) |
| SF-36 physical functioning scale | 173 | 48·53 (27·66) | 53·07 (25·35) | 48·82 (26·90) | 52·64 (27·90) |
| Pyrdinoline (nmol/l) | 18 | 64·80 (260·60) | n.a. | 4·12 (3·43) | 4·24 (2·74) |
| P1NP (ug/l) | 18 | 86·86 (52·66) | n.a. | 37·37 (22·72)* | 48·64 (23·03)† |
*
P < 0·05 adjusted for disease type compared with baseline.
1
One patient was unable to complete DLCO.
2
Adjusted for haemoglobin.
3
One patient did not complete the MHAQ and SF-36 physical functioning scale; n.a. = not applicable (pulmonary parameters and biomarkers were only measured at baseline, 12 and 24 weeks). DLCO: diffusion capacity for carbon monoxide; MHAQ: modified health assessment questionnaire; MRSS: modified Rodnan skin score; P1NP: aminoterminal propeptide of tyle I collagen; SF: short form.