Fig. 5.

Effect of resveratrol (RVT) and curcumin (CMN) on interleukin (IL)-1, IL-6, IL-10 and tumour necrosis factor (TNF)-α production. RVT and CMN were added in different concentrations (1, 5, 10, 20 μM) to lipopolysaccharide (LPS)-stimulated macrophages. The supernatants were collected after 48 h and cytokines were measured. All the data were calculated as pg/ml of IL-1 (a), IL-6 (b), TNF-α (c) and IL-10 (d), as computed by comparison with the standard curve using recombinant cytokines. Data expressed are the mean ± standard error (s.e.) from triplicate determinants. *P < 0·05 compared to the cytokines release by LPS-treated cells.