Table 3.
Activation/differentiation markers on CD4+ cells on IgAD, CVID and controls. Results are expressed as median ± standard deviation (s.d.).
| Controls (n = 65) | IgAD (n = 85) | CVID (n = 47) | P, IgAD controls | P, IgAD CVID | |
|---|---|---|---|---|---|
| CD4+ CD45RA+/CD4+ (%) | 44·9 ± 16·2 | 45·0 ± 14·4 | 24·3 ± 16·3 | 0·775 | < 0·0011* |
| CD4+ CD45RO+/CD4+ (%) | 49·7 ± 15·1 | 54·1 ± 15·1 | 75·4 ± 18·9 | 0·597 | < 0·0011* |
| CD4+ HLA-DR+/CD4+ (%) | 6·9 ± 6·4 | 3·9 ± 3·6 | 10·2 ± 8·2 | < 0·001* | < 0·001* |
| CD4+ CD25+/CD4+ (%) | 3·5 ± 3·1 | 9·7 ± 4·0 | 6·5 ± 7·9 | < 0·0011* | < 0·0011* |
| CD62L+ CD4+/CD4+ (%) | 75·3 ± 11·8 | 74·6 ± 11·2 | 71·9 ± 18·4 | 0·887 | 0·131 |
| CD4+ CD27+/CD4+ (%) | 89·0 ± 8·5 | 86·3 ± 7·9 | 85·9 ± 12·8 | 0·039 | 0·314 |
| CD4+ CD28+/CD4+ (%) | 98·3 ± 4·6 | 98·3 ± 3·6 | 95·6 ± 5·9 | 0·868 | < 0·0011* |
| CD4+ CD29+/CD4+ (%) | 50·4 ± 12·5 | 47·2 ± 13·4 | 65·3 ± 16·6 | 0·197 | < 0·0011* |
*
Indicates statistically significant difference using critical value after Bonferroni's correction: 0·006. CVID: common variable immunodeficiency; IgAD: selective deficiency of immunoglobulin A.