Table 4.
Activation/differentiation markers on CD8+ cells of IgAD, CVID and control. Results are expressed as median ± standard deviation (s.d.).
| Controls (n = 65) | IgAD (n = 85) | CVID (n = 47) | P, IgAD controls | P, IgAD CVID | |
|---|---|---|---|---|---|
| CD8+ CD45RA+/CD8+ (%) | 62·4 ± 13·5 | 58·5 ± 14·8 | 54·8 ± 16·2 | 0·197 | 0·131 |
| CD8+ CD45RO+/CD8+ (%) | 34·5 ± 13·6 | 28·9 ± 13·1 | 41·2 ± 14·2 | 0·010 | < 0·0011* |
| CD8+ CD57/CD8+ (%) | 17·3 ± 15·0 | 18·5 ± 12·9 | 34·7 ± 14·7 | 0·965 | < 0·0011* |
| CD8+ CD38/CD8+ (%) | 13·3 ± 8·3 | 10·0 ± 7·1 | 23·8 ± 17·0 | 0·014 | 0·0011* |
| CD8+ CD25+/CD8+ (%) | 1·1 ± 3·2 | 1·7 ± 5·6 | 0·6 ± 5·4 | 0·346 | < 0·0011* |
| CD8+ HLA-DR+/CD8+ (%) | 6·2 ± 6·2 | 2·4 ± 4·6 | 14·5 ± 15·8 | 0·280 | 0·0051* |
| CD62L+ CD8+/CD8+ (%) | 40·3 ± 17·5 | 39·2 ± 15·5 | 34·5 ± 19·1 | 0·603 | 0·151 |
| CD8+ CD27+/CD8+ (%) | 69·2 ± 19·2 | 58·0 ± 15·6 | 42·5 ± 22·4 | 0·022 | 0·0011* |
| CD8+ CD28+/CD8+ (%) | 65·7 ± 20·4 | 58·8 ± 17·9 | 35·6 ± 20·4 | 0·030 | 0·0021* |
| CD8+ CD29+/CD8+ (%) | 93·4 ± 7·4 | 79·1 ± 12·8 | 92·4 ± 21·7 | < 0·0011* | < 0·0011* |
*
Indicates statistically significant difference using critical value after Bonferroni's correction: 0·005. CVID: common variable immunodeficiency; IgAD: selective deficiency of immunoglobulin A.