Table 5.

Absolute and relative numbers of differentiation stages of B cells. CVID patients with B lymphocytes < 1% were excluded. Naive B lymphocytes were defined as: CD19⁺ CD27^– IgM⁺ IgD⁺ cells, IgM memory as: CD19⁺ CD27⁺ IgM⁺ IgD⁺ cells, switched memory as: CD19⁺ CD27⁺ IgM^– IgD^– cells, immature as CD19⁺ IgM⁺ CD21^–.

	Controls (n = 65)	IgAD (n = 85)	CVID (n = 40)	P, IgAD controls	P, IgAD CVID
Naive (109/l)	0·099 ± 0·053	0·111 ± 0·072	0·142 ± 0·139	0·308	0·271
IgM memory (109/l)	0·046 ± 0·025	0·043 ± 0·031	0·015 ± 0·043	0·902	< 0·0011*
Switched memory (109/l)	0·034 ± 0·038	0·028 ± 0·024	0·004 ± 0·012	0·108	< 0·0011*
IgM+ CD21– (109/l)	0·009 ± 0·011	0·012 ± 0·015	0·029 ± 0·064	0·034	< 0·0011*
Naive/B cells (%)	52.8 ± 12·5	56·8 ± 14·5	83·3 ± 15·8	0·135	< 0·0011*
Naive/PBL (%)	1·8 ± 1·1	1·6 ± 1·1	0·2 ± 0·6	0·203	< 0·0011*
IgM memory/B cells (%)	22·6 ± 7·4	20·5 ± 10·4	8·0 ± 12·3	0·520	< 0·0011*
Switched memory/B cells (%)	19·6 ± 7·5	14·9 ± 7·5	1·8 ± 3·8	0·039	< 0·0011*
IgM+ CD21–/B cells (%)	4·8 ± 4·3	6·7 ± 4·2	14·8 ± 14·8	0·025	< 0·0011*

^*Indicates statistically significant difference using critical value after Bonferroni's correction: 0·006. CVID: common variable immunodeficiency; IgAD: selective deficiency of immunoglobulin A.