Table 1.
Change of serum levels of beta2microglobulin (β2mg), neopterin (NPT) as well as 2–5 oligoadenylate synthetase (2–5 OAS) activity after the first injection of interferons (IFNs) in patients with chronic hepatitis C (CHC) and relapsing-remitting multiple sclerosis (RRMS).
| Chronic diseases | β2mg (µg/ml) | NPT (nmol/l) | 2–5 OAS (pmol/dl) |
|---|---|---|---|
| CHC | |||
| Pre-dose (T0) | 2·8 ± 0·8 (2·7)* | 7·2 ± 2·6 (6·6)* | 35·8 ± 24·2 (32)* |
| Post-dose (T24) | 3·6 ± 0·8 (3·5) | 20·1 ± 11·1 (18·2) | 91·6 ± 74·8 (78) |
| Increase (T24/T0) | 1·3 ± 0·2 (1·3) | 2·9 ± 1·8 (2·9) | 3·9 ± 4·7 (2·2) |
| T0versus T24/T0 correlation | r = −0·54 (P < 0·05) | r = −0·44 (P < 0·05) | r = −0·44 (P < 0·05) |
| RRMS | |||
| Pre-dose (T0) | 2·7 ± 0·8 (2·6)* | 9·2 ± 3·6 (9·6)* | 20·3 ± 14·6 (21·5) |
| Post-dose (T24) | 3·7 ± 0·8 (3·7) | 21·5 ± 9·2 (19·7) | 29·4 ± 19·8 (26·5) |
| Relative increase (T24/T0) | 1·3 ± 0·3 (1·3) | 2·5 ± 0·9 (2·3) | 2·2 ± 2·3 (1·5) |
| T0versus T24/T0 correlation | r = −0·57 (P < 0·05) | r = −0·47 (P < 0·05) | r = −0·53 (P < 0·05) |
Values are expressed in mean ± s.d. (median).
*
T0versus T24, P < 0·05.