Fig. 2.

Growth, survival rates in Sumf1^−/− mice. (a) Kaplan–Meyer survival curve of Sumf1^−/− mice (n = 39) over 180 days. (b) Mean weight values of WT (purple) and individual weight values of Sumf1^−/− mice (blue). Crosses indicate the age (days) of death of Sumf1^−/− mice. WT are the mean values of four (two females and two males) mice. Significant correlation between growth and survival rates is evident. (c) Sumf1^−/− mice (KO) are smaller than their WT littermates at P40. (d) Sumf1^−/− mice (on the left) display the typical flat facial profile of patients affected by MPSs.