Fig. 3.

Skeletal abnormalities in Sumf1^−/− mice. (a) Alizarin red- and Alcian blue-stained skeletons from a P30 WT and a Sumf1^−/− mouse. Growth retardation, spinal kyphosis, reduced length of long bones, and skull deformities are evident in the Sumf1^−/−mouse. (b) Facitron radiography of a P30 control mouse (Left) and a Sumf1^−/− littermate (Right) shows that the Sumf1^−/− skull is significantly shorter. (c) Loss of spinous process of dorsal vertebrae in P30 Sumf1^−/− mice (Right) compared with control (Left). (d) Analysis of distal tibia shows enlarged epiphysis and metaphysis in Sumf1^−/− mice (Right) compared with control (Left).