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. 2007 Mar 6;104(11):4506–4511. doi: 10.1073/pnas.0700382104

Fig. 7.

Fig. 7.

Massive apoptosis in Sumf1−/−. (a–c) In situ TUNEL analysis of liver sections of control (a), 1-month-old (b), and 3-month-old (c) Sumf1−/− mice shows a very high number of apoptotic cells in liver. (d and e) In situ TUNEL analysis of brain sections of Sumf1−/− mice shows few apoptotic cells in cerebral cortex in 2-month-old Sumf1−/− brain (d), whereas apoptosis is generalized in cerebral cortex at 6 month of age (e). (f) Apoptotic cell count in the brain cortex from 2- and 6-month-old Sumf1−/− mice and in 6-month-old control mice (values represent mean of n = 3 mice for each group; ∗, Student's t test P < 0.05).