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. Author manuscript; available in PMC: 2007 Mar 6.
Published in final edited form as: J Steroid Biochem Mol Biol. 2006 Nov 7;102(1-5):128–138. doi: 10.1016/j.jsbmb.2006.09.003

Fig. 6.

Fig. 6

Growth inhibition of MCF-7/5C tumors in response to E2 treatment, and resistance to FUL, and E2 plus FUL. Twenty ovariectomized athymic nude mice were bilaterally injected in the axillary mammary fat pads with 107 MCF-7/5C cells grown in culture and separated into 4 treatment groups of 5 mice each (10 tumors per group) corresponding to Control (no treatment), 0.3 cm E2 capsule sc, 2 mg/day FUL sc, and 0.3 cm E2 capsule sc + 2 mg/day FUL sc. The data are shown as a histogram on day 21 of the average tumor cross-sectional area (cm2) per group ± SE. The cross-sectional areas of Control-treated, FUL-treated, and E2 plus FUL-treated MCF-7/5C tumors were each significantly different from E2-treated (all P-values < 0.0001). However, the cross-sectional area of both FUL-treated and E2 plus FUL-treated MCF-7/5C tumors were not significantly different from that of control-treated MCF-7/5C tumors.