Figure 2.

Alignment of PRLIP amino acid sequences. Identical amino acids are shown in black boxes, whereas conserved amino acid changes are shaded in gray. The arrowheads above the sequence show the conserved Ser (S), Asp (D), and His (H) residues that can form a putative lipase catalytic triad. The conserved secondary structure elements, a sharp turn of a β-sheet, and an α-helix around the S residue are indicated with a line above the sequence. The position of introns are indicated by lowercase letters. The first intron is present in position a in all genes except in PRLIP8 where it is shifted downstream to position b; the second intron of PRLIP9 is in position c; whereas all genes of subgroup I have the second intron in position d. PRLIP3 and PRLIP8 have no second intron.