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. 2007 Feb;9(2):119–127. doi: 10.1593/neo.06616

Figure 6.

Figure 6

Effect of PD173074 therapy on apoptosis and neoangiogenesis in an orthotopic pancreatic cancer xenograft model. Animals bearing orthotopic pancreatic xenograft tumors were treated with PD173074 (B and D) or with vehicle (A and C), as described in Materials and Methods section. Animals were sacrificed, and tissue samples of the primary tumor were fixed in formalin (A and B) and liquid nitrogen (C and D). Sections of 3 µm were stained using the TUNEL method (A and B). Nuclei positively stained for DNA breaks are seen as black dots (B). In (C) and (D), MVD analysis of frozen tissue sections stained with an anti-CD31 antibody is shown. In (C), a xenograft tumor of an animal with an untreated xenograft tumor is shown, whereas in (D), a xenograft tumor of an animal receiving PD173074 is shown.