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. 2000 Mar 28;97(8):4070–4075. doi: 10.1073/pnas.080064097

Figure 5.

Figure 5

A model for the regulation of MEF2 activity by CaMK signaling. Hypertrophic signals that activate CaMK and MAPK lead to MEF2 activation by different mechanisms. Some stimuli, such as PE, may activate both pathways, whereas other stimuli may preferentially activate one pathway or the other. Association of HDACs 4/5 with the DNA-binding domain (DBD) of MEF2 represses MEF2 transcriptional activity. CaMK activates MEF2 by preventing association of HDACs 4/5 with MEF2. MAPK stimulates MEF2 activity by direct phosphorylation of the TAD. Together, the CaMK and MAPK pathways synergize to activate MEF2.