Fig. 4.

CD4⁺CD25⁺Foxp3⁺ BDC T cells induced by DCs and TGF-β1 block the development of diabetes in NOD.scid recipients. NOD.scid mice were injected i.v. with 10⁷ spleen cells from diabetic NOD females with either nothing (red triangles) or the indicated numbers of CD4⁺CD25⁺ BDC T cells from cultures with splenic DCs in the presence (+TGF-β1 BDC T, blue circles) or absence (−TGF-β1 BDC T, green squares) of TGF-β1. P < 0.0001, control vs. 3 × 10⁵ +TGF-β1 BDC T cells; P < 0.0001, control vs. 3 × 10⁴ +TGF-β1 BDC T cells.