Skip to main content
. Author manuscript; available in PMC: 2007 Mar 7.
Published in final edited form as: Neuropsychopharmacology. 2006 Jul 19;31(11):2368–2375. doi: 10.1038/sj.npp.1301163

Figure 3.

Figure 3

Behavioral response to PD 128907 is diminished in behaviorally sensitized rats. Locomotion following injection with saline and PD 128907 is shown following saline or AMPH pretreatment. Saline pretreatment group: *PD 128907 vs saline injection planned comparison p = 0.021, one-tailed. AMPH pretreatment group: PD 128907 vs saline injection planned comparison p = 0.754. Saline vs AMPH pretreatment group response to saline injection mean comparison p = 0.368, two-tailed. Methods: Male Sprague-Dawley were treated in home cages for 5 consecutive days with either saline or AMPH (1 mg/kg). On days 12–14, rats were injected in random order with either saline or PD 128907 (10 μg/kg) on a rotating basis, allowing each animal to be used as its own control to measure D3-agonist-mediated inhibitory effect. Data analysis by oneway ANOVA revealed no difference in order of injection (saline first or PD 128907 first). Crossover data from 0 to 180 min following injection with saline and PD 128907 were analyzed using ANOVA techniques for independent observations. Results are expressed as geometric mean number of crossovers, ±SE, for each group. Planned t-tests were performed for hypotheses of interest. Adapted from Richtand et al (2003).