TABLE 1.
Effect of CVS on physiological measures in experiment 1
| BW change (%) |
Thymus weight (mg) |
Thymus weight (mg/g BW) × 100 |
Adrenal weight (mg) |
Adrenal weight (mg/g BW) × 100 |
|
|---|---|---|---|---|---|
| 16 h | |||||
| Control (n = 24) | 14.3 ± 0.6 | 521 ± 20 | 184 ± 6 | 43.5 ± 1.0 | 15.5 ± 0.3 |
| CVS (n = 24) | 4.8 ± 0.6a | 460 ± 17 | 179 ± 7 | 44.8 ± 0.9 | 17.4 ± 0.3a |
| 4d | |||||
| Control (n = 12) | 18.5 ± 0.8 | 537 ± 34 | 189 ± 12 | 41.2 ± 0.9 | 14.1 ± 0.3 |
| CVS (n = 12) | 11.4 ± 1.3a | 493 ± 34 | 177 ± 10 | 46.6 ± 1.4a | 16.8 ± 0.3a |
| 7d | |||||
| Control (n = 12) | 22.0 ± 1.0 | 498 ± 22 | 163 ± 5 | 42.6 ± 1.6 | 14.0 ± 0.4 |
| CVS (n = 24) | 17.3 ± 0.8a | 489 ± 17 | 167 ± 4 | 46.5 ± 0.6a | 15.9 ± 0.2a |
| 30 d | |||||
| Control (n = 12) | 50.3 ± 3.7 | 430 ± 22 | 117 ± 5 | 46.8 ± 2.0 | 12.7 ± 0.4 |
| CVS (n = 12) | 49.0 ± 1.7 | 444 ± 21 | 122 ± 5 | 47.9 ± 1.5 | 13.3 ± 0.5 |
Rats were exposed to CVS for 7 d or were unhandled controls. At each recovery time point, six rats per group received novel environment exposure (5 min), whereas a different set of six rats per group were exposed to hypoxia (20 min). The total number of rats in each group is listed. Unstressed rats from the 16 h control (n = 12), 16 h CVS (n = 12), and 7 d CVS (n = 12) groups are included in this table. Time points reflect length of time after cessation of stress, and values represent the mean ± SEM of each group.
a
CVS is significantly different from corresponding control group (P < 0.05).