Table 1.
Isolated genes and their characterization
|
Specific apoptosis
|
||||
|---|---|---|---|---|
| Gene | Sublocalization | Known function | 28 h | 42 h |
| Cytochrome bL (CybL, CII-3, QPs-1, SDHC) | Mitochondria, inner membrane | e--Transport in complex II of the respiratory chain | 57.7% ± 8.6 | 59.7% ± 5.3 |
| Cytochrome bS (CybS, CII-4, QPs-3, SDHD) | Mitochondria, inner membrane | e--Transport in complex II of the respiratory chain | 18.4% ± 5.4 | 45.7% ± 0.5 |
| Adenine-nucleotide-translocator (ANT-1) | Mitochondria, inner membrane | ADP/ATP exchange in the PT-pore | 32.4% ± 3.5 | 94.0% ± 0.8 |
| Voltage-dependent anion channel-2 (VDAC-2, Porin) | Mitochondria, outer membrane | Pore formation in the PT-pore | 7.0% ± 3.8 | 55.9% ± 4.6 |
| Uncoupling protein-2 (UCP-2) | Mitochondria, inner membrane | Heat generation | 16.8% ± 4.7 | 22.2% ± 6.4 |
| Medium-chain acyl-CoA dehydrogenase | Mitochondria, matrix | β-Oxidation of fatty acids | 20.7% ± 1.1 | 37.6% ± 3.0 |
| Kynurenine 3-monooxygenase | Mitochondria, outer membrane | Hydroxylation of kynurenine | 16.1% ± 1.2 | 60.7% ± 5.0 |
| Very-long-chain acyl-CoA synthetase | Membranes of peroxisomes, endoplasmic reticulum | Metabolism of very-long-chain fatty acids | 31.4% ± 0.5 | 55.3% ± 6.8 |
| Cytochrome b-558 | Plasma membrane | H2O2 generation by NADPH oxidation | 32.9% ± 4.2 | 51.5% ± 6.0 |
| Hemoglobin alpha (Hba-α1) | Cytosol | O2 Transport | 22.1% ± 4.8 | 52.7% ± 12.9 |
| Serine palmitoyltransferase, subunit 2 | Endoplasmic reticulum | Sphingolipid synthesis | 64.3% ± 4.8 | 90.7% ± 1.4 |