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A possible model for Vsm1 regulation of Sso t-SNARE availability. In yeast, Sso exists in either a closed inactive conformation (Off) or an open active conformation, which binds its Sec9 t-SNARE partner (On). Phosphorylation of Sso by PKA recruits Vsm1, stabilizes the closed conformation of the t-SNARE, and inhibits Sec9 binding. Dephosphorylation of Sso by a CAPP releases Vsm1, stabilizes the open conformation of the t-SNARE, and leads to Sec9 binding.
