Figure 5.

Localization CD1c in immature and mature DCs. CD1c molecules are present in the multilamellar structures (A; 10-nm gold) and in early endosomes of IMDCs (B; 15-nm gold). Maturation of IMDCs to MDCs (C) shows the presence of CD1c molecules (15-nm gold, closed arrowheads) in MDLs (indicated by asterisks) and in early endosomes, whereas MHC class II molecules (10-nm gold, open arrowheads) are mostly present on the plasma membrane. Scale, 200 nm. p, plasma membrane; G, Golgi complex; e, endosomes; and m, mitochondria.