Table 1.

The tyrosine-based sorting motifs of relevant transmembrane proteins

CD1a*	TM-RKRCFC
CD1b	TM-RRRSYQNIP
CD1c	TM-KKHCSYQDIL
CD1d	TM-KRQTSYQGVL
LAMP-1	TM-RKRSHAGYQTI
LAMP-2	TM-KHHHAGYEQF
CD63	TM-KSIRSGYEVM
M6PR	TM-24aa-YKYSKV-135aa
Transferrin receptor	17aa-LSYTRF-45aa-TM

The sequences of the cytoplasmic tails are depicted for CD1a, CD1b, CD1c, and CD1d, lysosomal proteins LAMP1, LAMP2, and CD63, and early endosomal transferrin receptor, late endosomal CI mannose-6-phosphate receptor. TM denotes the transmembrane domain and the YXXØ motif is underlined. The tyrosine (Y) and the bulky hydrophobic residues are bold typed.

^*Note CD1a lacks the tyrosine motif.