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. 2006 May 18;574(Pt 3):787–803. doi: 10.1113/jphysiol.2006.111310

Figure 4. The BDNF scavenger TrkB-IgG prevents the enhancement of FM1-43 release from the RRP after LTP induction.

Figure 4

A, average initial raw FM1-43 fluorescence intensities of RRP-labelled terminals from control slices, and in slices after LTP induction in the absence and presence of the BDNF scavenger TrkB-IgG. FM1-43 staining was performed using sucrose to selectively load the RRP (Student's t test, *P < 0.05, **P < 0.001). B, time course of evoked FM1-43 destaining from the RRP in control slices (open circles) versus slices where LTP was induced (filled circles), showing the enhanced vesicular release from the RRP after LTP induction in area CA1. The vertical bars indicate the stimulation to the afferent fibres consisting of 10 Hz 2 s bursts every 30 s throughout and synchronized with image acquisition. The enhanced rate of activity-dependent release from the RRP after LTP induction is completely prevented by application of the BDNF scavenger TrkB-IgG before the LTP-inducing stimuli (filled triangles).