Table 1.
Subject characteristics
| Characteristic | Arg16 (n = 15) | Gly16 (n = 17) | P |
|---|---|---|---|
| Sex (female/male) | 8/7 | 7/10 | 0.72 |
| Age (years) | 29 ± 8 | 31 ± 7 | 0.36 |
| Height (cm) | 174 ± 8 | 173 ± 11 | 0.84 |
| Weight (kg) | 71 ± 11 | 74 ± 10 | 0.48 |
| HR (beats min−1) | 66 ± 6 | 67 ± 9 | 0.90 |
| BMI (kg m−2) | 22.9 | 23.9 | 0.30 |
| BSA (m2) | 1.8 ± 0.2 | 1.9 ± 0.2 | 0.58 |
| Cholesterol (mmol l−1) | 4.14 ± 0.81 | 4.61 ± 0.80 | 0.11 |
| Triglycerides (mmol l−1) | 2.00 ± 0.70 | 2.53 ± 0.29 | 0.13 |
| HDL (mmol l−1) | 1.33 ± 0.38 | 1.37 ± 0.32 | 0.94 |
| LDL (mmol l−1) | 2.41 ± 0.78 | 2.74 ± 0.70 | 0.17 |
| SBP (mmHg) | 102.7 ± 10.1 | 108.0 ± 9.0 | 0.13 |
| Low-Na+ SBP (mmHg) | 102.0 ± 9.4 | 100.6 ± 7.4* | 0.64 |
| DBP (mmHg) | 69.0 ± 7.7 | 70.9 ± 8.1 | 0.50 |
| Low-Na+ DBP (mmHg) | 67.5 ± 12.1 | 71.6 ± 5.6 | 0.23 |
| MAP (mmHg) | 80.1 ± 7.9 | 83.3 ± 8.1 | 0.28 |
| Low-Na+ MAP (mmHg) | 79.0 ± 11.0 | 81.2 ± 5.5 | 0.47 |
Values are means ± s.d. All values were recorded during the screening visit, except for the low-Na+ blood pressure values, which were measured by random zero sphygmomanometry on the morning of study day 6 after 5 days of low-Na+ diet (10 mmol day−1). The groups were compared by using the Wilcoxin rank-sum for all variables except gender, which was compared by Fischer's exact test. BMI, body mass index; BSA, body surface area; DBP, diastolic blood pressure; HDL, high density lipoprotein; LDL, low density lipoprotein; SBP, systolic blood pressure.
*
Gly16 group before versus after diet demonstrated a significant decrease in SBP after the low-Na+ diet (P = 0.003, paired t test).