Figure 2. Morphological characteristics of Beethoven cochleae.

A, low-resolution SEM of +/+, Bth/+ and Bth/Bth at P15 from the same three cochlear regions as in Fig. 1A, B and C, SEM of Bth/Bth at P30 and P60, respectively. Bth/Bth cochleae show degeneration of both hair cell types in the 40–50% and 10–20% regions at all ages. No clear signs of degeneration were observed in the apical region (80–90%) of P15 Bth/Bth, or in any region of P15 Bth/+ cochleae. Scale bar represents 5 μm.