Table 1.

Effects of methazolamide (MTZ) and acetazolamide (AZ) on the steady-state hypoxic ventilatory response in 10 cats

	Control	MTZ	AZ
G (l min−1)	1.93 ± 1.32	1.89 ± 0.90	1.09 ± 0.92*
D (kPa−1)	0.20 ± 0.07	0.22 ± 0.06	0.14 ± 0.06
A (l min−1)	0.86 ± 0.33	1.30 ± 0.401	1.32 ± 0.432
Pa,CO2 (kPa)	4.63 ± 0.75	4.55 ± 0.78	4.78 ± 0.81
Pa,CO2–PET,CO2 (kPa)	−0.01 ± 0.30	−0.08 ± 0.38	0.29 ± 0.613
Arterial pH	7.338 ± 0.04	7.307 ± 0.054	7.253 ± 0.055
Base excess (mm)	−6.75 ± 1.26	−8.56 ± 1.836	−10.53 ± 1.977

G, hypoxic sensitivity; D, shape parameter; A, hyperoxic ventilation; P_a,CO2−P_ET,CO2, arterial–end-tidal P_CO2 gradient.

^*P = 0.003 versus control and 0.010 versus MTZ;

¹P = 0.003 versus control;

²P = 0.002 versus control;

³P = 0.007 versus control;

⁴P = 0.007 versus control;

⁵P = 0.000 versus control;

⁶P = 0.006 versus control;

⁷P = 0.000 versus control.

Blood gas and acid–base data are means of the means per cat.