Interleukins in serum and interstitial fluid from fore paw, hind paw, thigh and back skin of young (3–4 months) and old (11–13 months) adult Chy and wt mice. A, interleukin-4 levels in young adult mice; B, interleukin-2 levels in old adult mice; C, interleukin-6 levels in old adult mice. Values are presented as mean ± s.d. *P < 0.05, significant difference (unpaired t test) between Chy and wt mice within the same area of measurement. †P < 0.05 when compared with corresponding serum.