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. 2006 May 11;574(Pt 1):229–243. doi: 10.1113/jphysiol.2005.104042

Figure 2. ZD 7288 affects passive, but not active membrane properties of fast-spiking BCs.

Figure 2

A, traces of APs evoked by 2.4 nA, 0.5-ms current pulses. Black trace, control; red trace, 30 μm ZD 7288. The cell was held at −70 mV by holding current adjustment throughout the experiment. B, traces of APs evoked by 800-pA, 800-ms current pulses. Black trace, control; red trace, 30 μm ZD 7288. C–G, summary graphs of the effects of ZD 7288 on maximal rate of rise (C), AP peak amplitude (D), AP duration at half-maximal amplitude (E), fast afterhyperpolarization (AHP) (F) and slow AHP (G). All parameters were measured for single APs evoked by brief current pulses. H, summary graph of the effects of ZD 7288 on maximal AP frequency. Frequency was determined for trains of APs evoked by 800-pA, 800-ms pulses. Bars represent mean values, circles indicate data from individual experiments. Data from 10 BCs. In all experiments, 10 μm CNQX, 20 μm D-AP5 and 20 μm BIC were added to the bath solution.