C-tau immunolabeling in the striatum and dentate gyrus regions of the hippocampus. Immunocytochemistry was performed with an antibody specific to cleaved MAP-tau (C-tau7) and striatal (panels A, C, E) and hippocampal (panels B, D, F) tissue of rats killed 3 days after treatment with VEH (panels A and B), METH (panels C and D) or MDMA (panels E and F). Drugs were administered as described in the legend of Table 1. Magnification, 20x.