Table 1.

Striatal dopamine and serotonin depletions produced by the psychostimulant drugs amphetamine, methamphetamine, ± 3,4 methylenedioxymethamphetamine, or para-methoxyamphetamine. Concentrations of dopamine (DA) and serotonin (5-HT) in the striatum of rats were determined 3 days after treatment with vehicle (saline, i.p.), amphetamine (AMPH; iprindole (10 mg/kg, i.p.) followed 1 hour later by AMPH (9.2 mg/kg, i.p.)) methamphetamine (METH; a total of 4 injections consisting of 2 i.p. injections of 10 mg/kg, and 1 i.p. injection each of 7.5 mg/kg and 5 mg/kg spaced 2 hours apart), ±3,4-methylenedioxymethamphetamine (MDMA; 10 mg/kg, i.p., given every 2 hours for 4 injections), or para-methoxyamphetamine (PMA; 10 mg/kg, i.p. given every two hours for four injections). Values represent the mean ± SEM. Numbers in parentheses equals the number of determinations.

Drug	DA (ng/mg tissue ± SEM)	5-HT (ng/mg tissue ± SEM)
Vehicle	11.9 ± 0.43 (17)	0.41 ± 0.03 (17)
AMPH	2.2 ± 0.80*** (6)	0.36 ± 0.04 (6)
METH	4.2 ± 0.79*** (7)	0.26 ± 0.03*** (7)
MDMA	10.3 ± 0.83 (7)	0.26 ± 0.02** (7)
PMA	10.8 ± 0.62 (7)	0.27 ± 0.03** (7)

^***P < 0.001 and

^**P < 0.01 compared to vehicle-treated rats.