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Levels of antigen-specific immune responses and antitumour protection by E7 expression DNA cassettes
| DNA constructs | Antibody | CD4+ T (Th1) | CTL (CD8) | Prophylactic responses | Therapeutic responses |
|---|---|---|---|---|---|
| pcDNA3-LacZ | – | – | – | – | – |
| pcDNA3-E7 | – | – | – | – | – |
| pcDNA3-Sig/E7 | – | – | +/– | + | – |
| pcDNA3-Sig/E7/TMR | – | – | +/– | +/– | – |
| pcDNA3-Sig/E7/LAMP | – | – | + | + + | + |
| pcDNA3-Sig/sE7/LAMP | + | – | + + + | + + + + + | + + |
| pIn2-eE7 (sE7) | ND | ND | ND | – | – |
More + represents stronger responses; – represents no responses; ND, not determined.
