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. 2005 Oct;116(2):203–212. doi: 10.1111/j.1365-2567.2005.02211.x

Figure 4.

Figure 4

Differences in the induction of tolerance and cross-tolerance in vivo. Mice were pretreated intraperitoneally (i.p.) with NaCl, lipopolysaccharide (LPS) (2 µg/kg), lipoteichoic acid (LTA) (100 mg/kg) or CpG-oligodesoxynucleotides (ODN) (500 nmol/kg) 24 hr prior to i.p. challenge with galactosamine (GalN) (0·75 g/kg) and the indicated Toll-like receptor (TLR) stimulus at the same dose used for pretreatment. Circulating blood levels of tumour necrosis factor (TNF)-α (a, c, e) were determined 90 min later and alanine aminotransferase (ALT) plasma activities (b, d, f) were measured after 7 hr. Displayed are mean values + standard error of the mean (six mice in each group). *P < 0·05; **P < 0·01; ns, not significant (Dunnett's multiple comparison test).