Table 2.
Comparison of mean values (± SEM, n = 9–17 mice per group) for behavioral observations in the open field test between WT (+/+) and KO (−/−) female mice
| Parameter | Two to three mo of age |
Fifteen to seventeen mo of age |
||
|---|---|---|---|---|
| +/+ | −/− | +/+ | −/− | |
| Time spent on the periphery, s | 132.1 ± 23.2 | 146.3 ± 12.8 | 126.0 ± 15.3 | 133.9 ± 11.7 |
| Time spent in the center, s | 22.5 ± 5.7 | 36.6 ± 10.2 | 20.4 ± 4.7 | 52.7 ± 6.8*† |
| Risk assessment | 2.0 ± 0.4 | 3.0 ± 1.2 | 5.1 ± 0.8† | 2.9 ± 0.9* |
| Time spent self-grooming, s | 3.9 ± 0.07 | 4.6 ± 0.7 | 13.5 ± 4.9† | 4.8 ± 0.7 |
| Time spent freezing, s | 3.4 ± 0.9 | 3.1 ± 0.7 | 3.2 ± 0.6 | 1.2 ± 0.6†‡ |
| Horizontal activity | 592.5 ± 103.0 | 750.8 ± 82.0 | 612.7 ± 50.6 | 697.5 ± 55.3 |
| Vertical activity | 49.4 ± 13.0 | 36.6 ± 10.2 | 38.7 ± 6.4 | 63.5 ± 9.8‡ |
*, P < 0.01 vs. corresponding age-matched WT value.
†, P < 0.05 within each genotype comparing young adult (2–3 mo) and aged (15–17 mo) female mice.
‡, P < 0.05 vs. corresponding age-matched WT value.