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. Author manuscript; available in PMC: 2007 Oct 1.
Published in final edited form as: Alcohol. 2006 Oct;40(2):111–118. doi: 10.1016/j.alcohol.2006.11.001

Fig. 2. Prolonged EtOH Exposure Results in a Persistent Elevation in GDP Frequency.

Fig. 2

(A) Sample trace demonstrating a reversible increase in GDP frequency in CA3 pyramidal neurons from control slices acutely treated with EtOH for 7 minutes. (B) Summary of the effect of acute ETOH exposure on GDP frequency (n = 11). ***p < 0.001 by repeated measures ANOVA followed by Tukey’s posthoc test. (C) Sample traces from the sister slice of 2A treated with 50 mM EtOH for a period of 3 to 4 hrs. The frequency of GDPs decreases following EtOH washout. (D) Summary of the effect prolonged EtOH exposure on GDP frequency (n = 12). The basal GDP frequency during prolonged ETOH exposure was significantly higher than the baseline frequency of acutely exposed slices (0.35 ± 0.02 Hz vs 0.26 ± 0.01 Hz; <0.01 by unpaired t-test). The percent change in GDP frequency between acute-ETOH and prolonged-EtOH slices was not statistically different by unpaired t-test (31 ± 5 % vs. 25 ± 7 %). ***p < 0.001 by paired t-test. Scale bar for both traces = 100 pA/4 s.