Table 1.
Example of UV cytotoxicity and mutagenicity in parental cell strain MSU-1.2-7AGM and two derivative cell strains expressing hREV1 antisense RNA
| Cell strain | UV (J/m2) | Percent survival | Cells selected (×106) | Mutants observed | Cloning efficiency (%) | Mutant frequency (×106) | Induced frequency (×106) |
|---|---|---|---|---|---|---|---|
| 7AGM | 0 | 100 | 1 | 4 | 40 | 10 | 0 |
| 10 | 62 | 1 | 18 | 36 | 50 | 40 | |
| 12 | 52 | 1 | 22 | 40 | 55 | 45 | |
| 7AGM | 0 | 100 | 1.8 | 2 | 24 | 5 | 0 |
| 17C- | 11 | 47 | 1.8 | 6 | 24 | 14 | 9 |
| R1 | 13 | 33 | 1.8 | 12 | 21 | 32 | 27 |
| 15 | 20 | 1.8 | 7 | 21 | 19 | 14 | |
| 7AGM | 0 | 100 | 1 | 0 | 33 | 0 | 0 |
| 12B- | 11 | 57 | 1 | 0 | 32 | 0 | 0 |
| R1 | 13 | 35 | 1.5 | 1 | 32 | 2 | 2 |
| 15 | 26 | 1.5 | 0 | 30 | 0 | 0 |