Table 1.

Competition of disruption strains against wild type

Strain	s	R	n	P
TD84*	0.228  ±  0.046	0.992	5	<0.001
TD24*	0.220  ±  0.061	0.992	4	<0.001
TD88	0.216  ±  0.157	0.870	5	<0.05
TD83*	0.215  ±  0.075	0.977	5	<0.001
TD30*	0.159  ±  0.022	0.994	4	<0.001
TD87	0.104  ±  0.025	0.994	4	<0.001
TD66*	0.098  ±  0.018	0.993	5	<0.001
TD92†	0.094  ±  0.014	0.996	5	<0.001
TD10	0.090  ±  0.018	0.988	6	<0.001
TD37	0.058  ±  0.008	0.992	7	<0.001
TD61	0.045  ±  0.010	0.981	7	<0.001
TD64	0.045  ±  0.007	0.993	6	<0.001
TD2	0.013  ±  0.003	0.938	8	<0.001
TD8	0.013  ±  0.004	0.928	12	<0.001
TD19	0.012  ±  0.001	0.996	9	<0.001
TD23	0.011  ±  0.003	0.923	8	<0.01
TD48	0.010  ±  0.003	0.982	5	<0.001
TD27	0.006  ±  0.003	0.922	7	<0.01
TD79	0.006  ±  0.004	0.889	6	<0.01
TD52	0.006  ±  0.004	0.847	7	<0.01
TD21	0.005  ±  0.001	0.968	8	<0.001
TD80	0.005  ±  0.003	0.871	7	<0.01
TD63	0.004  ±  0.001	0.972	10	<0.001
TD4	0.003  ±  0.002	0.679	13	<0.01
TD53	0.003  ±  0.003	0.804	7	<0.02
TD90	0.005  ±  0.006	0.586	8	NS
TD9	0.005  ±  0.004	0.468	11	NS
TD16	0.003  ±  0.004	0.241	12	NS
TD50	0.001  ±  0.001	0.494	10	NS
TD60	0.001  ±  0.002	0.508	9	NS
TD1‡	−0.001  ±  0.005	0.401	5	NS
TD6	−0.002  ±  0.004	0.344	8	NS
TD7	−0.005  ±  0.004	0.641	12	<0.05
TD5	−0.007  ±  0.004	0.800	10	<0.01

Selection coefficients (s) were measured as in Fig. 1. Strains are arranged in descending order of the estimated selection coefficient. The final three columns report the correlation coefficient (R), the number of time points at which genotype frequencies were measured (n), and the statistical significance (P) for a test of the null hypothesis that the slope is not different from zero. NS, not significant.

^*Produces small colonies on rich medium, fails to grow with glycerol as primary carbon source (petite).

^†Produces small colonies on rich medium, marginal growth with glycerol as primary carbon source.

^‡Produces small colonies on minimal medium.