Table 1.
Genes up-regulated by sepsis in the lung of the baboons at 2, 8 and 24 hr post E. coli challenge
| Gene Accession no. | Gene Product | Fold change compared to control | ||
| 2 h | 8 h | 24 h | ||
| Cytokine or chemokine | ||||
| NM_002089 | chemokine (C-X-C motif) ligand 2 (CXCL2) | 10.8 | ||
| NM_004591 | chemokine (C-C motif) ligand 20 (CCL20) | 8.3 | ||
| NM_000576 | interleukin 1, beta (IL1B) | 4.5 | ||
| NM_005409 | chemokine (C-X-C motif) ligand 11 (CXCL11) | 4.4 | 10.5 | |
| NM_001565 | chemokine (C-X-C motif) ligand 10 (CXCL10) | 4.3 | ||
| NM_002982 | chemokine (C-C motif) ligand 2 (CCL2) | 3.5 | ||
| NM_002198 | interferon regulatory factor 1 (IRF1) | 3.0 | 3.8 | |
| NM_000600 | interleukin 6 (interferon, beta 2) (IL6) | 2.2 | ||
| NM_002189 | interleukin 15 receptor, alpha (IL15RA) | 2.2 | ||
| NM_002984 | chemokine (C-C motif) ligand 4 (CCL4) | 2.2 | ||
| NM_000759 | colony stimulating factor 3 (granulocyte) (CSF3) | 4.4 | ||
| D90145 | chemokine (C-C motif) ligand 3-like 1(CCL3L1) | 2.6 | 3.0 | 2.0 |
| Cytokine suppression or regulation | ||||
| X52015 | interleukin 1 receptor antagonist (IL1RN) | 2.8 | ||
| Adhesion molecules | ||||
| NM_001078 | vascular cell adhesion molecule 1 (VCAM1) | 6.9 | 4.7 | |
| NM_000201 | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor (ICAM1) | 3.5 | ||
| NM_001816 | carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) | 2.0 | ||
| NM_021219 | junctional adhesion molecule 2 (JAM2) | 2.0 | 2.3 | |
| NM_003370 | vasodilator-stimulated phosphoprotein (VASP) | 2.3 | 2.1 | |
| AF139768 | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5 | 2.01 | ||
| NM_002999 | syndecan 4 (amphiglycan, ryudocan) (SDC4) | 6.0 | ||
| Other inflammation-associated genes | ||||
| NM_004120 | guanylate binding protein 2, interferon-inducible (GBP2) | 10.2 | 16.3 | 2.3 |
| NM_002053 | guanylate binding protein 1, interferon-inducible, 67 kDa (GBP1) | 3.8 | 4.5 | |
| NM_006291 | tumor necrosis factor, alpha-induced protein 2 (TNFAIP2) | 3.4 | ||
| NM_006058 | TNFAIP3 interacting protein 1 (TNIP1) | 2.9 | ||
| NM_006290 | tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) | 2.5 | ||
| NM_003821 | receptor-interacting serine-threonine kinase 2 (RIPK2) | 2.1 | ||
| NM_002964 | S100 calcium binding protein A8 (calgranulin A) (S100A8) | 12.0 | 27.5 | 6.2 |
| NM_002965 | S100 calcium binding protein A9 (calgranulin B) (S100A9) | 7.7 | 17.5 | |
| NM_007053 | CD160 antigen (CD160) | 2.2 | 2.0 | |
| NM_001276 | chitinase 3-like 1 (cartilage glycoprotein-39) (CHI3L1) | 3.2 | 2.5 | |
| NM_004271 | lymphocyte antigen 86 (LY86) (MD-1) | 2.3 | ||
| NM_001085 | serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (SERPINA3) | 5.6 | 6.8 | |
| NM_002818 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) (PSME2) | 3.1 | ||
| NM_004159 | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) (PSMB8) | 3.2 | ||
| Hypoxia and/or oxidative stress | ||||
| NM_001530 | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF1A) | 2.9 | 2.5 | |
| NM_003330 | thioredoxin reductase 1 (TXNRD1) | 2.1 | ||
| NM_000636 | superoxide dismutase 2, mitochondrial (SOD2) | 12.5 | 5.0 | |
| AK055872 | Haptoglobin (HP) | 33.3 | 24.4 | |
| Apoptosis | ||||
| AF070674 | baculoviral IAP repeat-containing 3 (BIRC3) | 2.9 | ||
| NM_015675 | growth arrest and DNA-damage-inducible, beta (GADD45B) | 3.0 | ||
| NM_002727 | proteoglycan 1, secretory granule (PRG1) | 2.3 | 2.4 | |
| NM_052889 | CARD only protein (COP) | 9.6 | 11.8 | |
| NM_003311 | pleckstrin homology-like domain, family A, member 2 (PHLDA2) | 3.1 | ||
| NM_005734 | homeodomain interacting protein kinase 3 (HIPK3) | 2.0 | ||
| NM_016426 | G-2 and S-phase expressed 1 (GTSE1) | 2.0 | ||
| NM_005456 | mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1) | 2.3 | ||
| Heat shock protein | ||||
| NM_014365 | heat shock 27 kDa protein 8 (HSPB8) | 3.0 | 2.7 | |
| Cell proliferation tumor suppressor wound healing process | ||||
| NM_003311 | pleckstrin homology-like domain, family A, member 2 (PHLDA2) | 2.8 | ||
| NM_021077 | neuromedin B (NMB) | 2.0 | ||
| NM_006069 | murine retrovirus integration site 1 homolog (MRVI1) | 2.7 | ||
| NM_001260 | cyclin-dependent kinase 8 (CDK8) | 2.7 | ||
| NM_003073 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1) | 2.4 | ||
| AK055327 | fibroblast activation protein, alpha (FAP) | 4.3 | ||
| NM_005424 | tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (TIE) | 2.9 | ||
| NM_002408 | mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT2) | 2.9 | ||
| NM_020638 | fibroblast growth factor 23 (FGF23) | 2.3 | ||
| NM_006603 | stromal antigen 2 (STAG2) | 2.3 | ||
| NM_005622 | SA hypertension-associated homolog (rat) (SAH) | 2.3 | ||
| AB011537 | slit homolog 1 (Drosophila) (SLIT1) | 2.2 | ||
| J05158 | carboxypeptidase N, polypeptide 2, 83 kD (CPN2) | 2.1 | ||
| AF339822 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1) | 2.2 | 3.2 | |
| AK056352 | PR domain containing 5 (PRDM5) | 2.0 | 2.5 | |
| AL117643 | activin A receptor, type IB (ACVR1B) | 2.4 | ||
| Coagulation | ||||
| NM_001993 | coagulation factor III (thromboplastin, tissue factor) (F3) | 2.5 | ||
| NM_014059 | response gene to complement 32 (RGC32) | 3.7 | ||
| Blood pressure | ||||
| NM_024409 | natriuretic peptide precursor C (NPPC) | 2.8 | ||
| Energy generation | ||||
| AF327403 | solute carrier family 25, member 28 (SLC25A28) | 2.1 | ||
| NM_000761 | cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2) | 3.5 | 3.4 | |
| AL359600 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (ABCC5) | 2.3 | ||
| AF052090 | nicotinamide nucleotide transhydrogenase (NNT) | 2.7 | ||
| NM_004297 | guanine nucleotide binding protein (G protein), alpha 14 (GNA14) | 2.1 | ||
| Protein synthesis | ||||
| AL161952 | glutamate-ammonia ligase (glutamine synthase) (GLUL) | 2.1 | ||
| NM_004184 | tryptophanyl-tRNA synthetase (WARS) | 2.1 | 8.0 | 3.4 |
| NM_002954 | ribosomal protein S27a (RPS27A) | 2.1 | ||
| NM_013417 | isoleucine-tRNA synthetase (IARS) | 2.0 | ||
| Cation transporter | ||||
| NM_017964 | solute carrier family 30 (zinc transporter), member 6 (SLC30A6) | 2.0 | ||
| NM_022154 | solute carrier family 39 (zinc transporter), member 8 (SLC39A8) | 4.4 | 3.6 | |
| D31887 | solute carrier family 39 (zinc transporter), member 14 (SLC39A14) | 2.2 | ||
| Transcriptional regulation | ||||
| NM_020529 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA) | 6.2 | ||
| AK026497 | YY1 transcription factor (YY1) | 2.6 | ||
| NM_004556 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon (NFKBIE) | 2.4 | ||
| NM_013448 | bromodomain adjacent to zinc finger domain, 1A (BAZ1A) | 2.0 | ||
| NM_015859 | general transcription factor IIA, 1, 19/37 kDa (GTF2A1) | 2.1 | ||
| NM_004697 | PRP4 pre-mRNA processing factor 4 homolog (yeast) (PRPF4) | 2.7 | ||
| NM_005523 | homeo box A11 (HOXA11) | 2.1 | ||
| NM_006540 | nuclear receptor coactivator 2 (NCOA2) | 3.5 | ||
| NM_012345 | nuclear fragile × mental retardation protein interacting protein 1 (NUFIP1) | 3.4 | ||
| NM_004719 | splicing factor, arginine/serine-rich 2, interacting protein (SFRS2IP) | 3.3 | ||
| NM_004514 | forkhead box K2 (FOXK2) | 3.1 | ||
| BG163465 | I-mfa domain-containing protein (HIC) | 2.0 | ||
| AK025842 | nuclear receptor subfamily 2, group F, member 2 (NR2F2) | 2.0 | ||
| Cell motility, phagocytosis, trafficking | ||||
| NM_002356 | myristoylated alanine-rich protein kinase C substrate (MARCKS) | 3.0 | ||
| NM_006086 | tubulin, beta, 4 (TUBB4) | 2.5 | 3.5 | |
| AK023457 | RAP1A, member of RAS oncogene family (RAP1A) | 2.7 | ||
| Lipid | ||||
| AF323540 | apolipoprotein L, 1 (APOL1) | 3.7 | 12.4 | |
| NM_005564 | lipocalin 2 (oncogene 24p3) (LCN2) | 8.6 | 10.7 | |
| NM_004190 | lipase, gastric (LIPF) | 2.1 | ||
| Protein glycosylation | ||||
| NM_004737 | like-glycosyltransferase (LARGE) | 2.3 | ||
| AB067505 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13) | 2.0 | ||
| NM_006042 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 (HS3ST3A1) | 2.1 | ||
| AF155510 | Heparanase (HPSE) | 2.1 | ||
| NM_005424 | yrosine kinase with immunoglobulin and epidermal growth factor homology domains (TIE) | 2.9 | ||
| NM_002408 | mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT2) | 2.9 | ||
| NM_006577 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) | 3.3 | ||
| Signal transduction | ||||
| NM_002401 | mitogen-activated protein kinase kinase kinase 3 (MAP3K3) | 3.0 | ||
| NM_001721 | BMX non-receptor tyrosine kinase (BMX) | 2.6 | ||
| NM_004297 | guanine nucleotide binding protein (G protein), alpha 14 (GNA14) | 2.1 | ||
| NM_002075 | guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3) | 2.6 | 2.2 | |
| BC011671 | guanine nucleotide binding protein (G protein), beta 5 (GNB5) | 2.7 | ||
| NM_004125 | guanine nucleotide binding protein (G protein), gamma 10 (GNG10) | 2.2 | 2.5 | |
| NM_005279 | G protein-coupled receptor 1 (GPR1) | 3.3 | ||