Table 2.
Genes downregulated by sepsis in the lung of the baboons at 2, 8 and 24 hrs post E. coli challenge
| Gene Accession no. | Gene Product | Fold change compared to control | ||
| 2 h | 6–8 h | 24 h | ||
| Cytokine, chemokine, inflammation associated gene | ||||
| NM_001243 | tumor necrosis factor receptor superfamily, member 8 (TNFRSF8) | 0.23 | 0.18 | |
| NM_000014 | alpha-2-macroglobulin (A2M) | 0.48 | ||
| NM_002994 | chemokine (C-X-C motif) ligand 5 (CXCL5) | 0.50 | ||
| NM_004763 | integrin beta 1 binding protein 1 (ITGB1BP1) | 0.50 | ||
| Immune response | ||||
| NM_000587 | complement component 7 (C7) | 0.32 | ||
| NM_002125 | major histocompatibility complex, class II, DR beta 3 (HLA-DRB3) | 0.33 | ||
| Scaffolding protein | ||||
| NM_001753 | Caveolin 1 protein (CAV1) | 0.49 | ||
| Blood coagulation | ||||
| NM_000361 | Thrombomodulin (THBD) | 0.39 | 0.17 | 0.25 |
| NM_000611 | CD59 antigen p18–20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59) | 0.42 | ||
| NM_001150 | alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase) (ANPEP) | 0.43 | ||
| Collagen catabolism, extra cellular matrix | ||||
| NM_004530 | matrix metalloproteinase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase) (MMP2) | 0.36 | 0.36 | |
| AL110197 | tissue inhibitor of metalloproteinase 2 (TIMP2) | 0.46 | 0.45 | |
| NM_001848 | collagen, type VI, alpha 1 (COL6A1) | 0.48 | ||
| NM_004369 | collagen, type VI, alpha 3 (COL6A3) | 0.30 | ||
| NM_000362 | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) (TIMP3) | 0.32 | ||
| Cell adhesion, cell migration | ||||
| NM_001901 | connective tissue growth factor (CTGF) | 0.37 | ||
| AY027862 | upregulated in colorectal cancer gene 1 (UCC1) | 0.40 | ||
| NM_001769 | CD9 antigen (p24) (CD9) | 0.30 | ||
| NM_002026 | fibronectin 1 (FN1) | 0.37 | ||
| AL050364 | plakophilin 4 (PKP4) | 0.44 | 0.43 | |
| NM_001305 | claudin 4 (CLDN4) | 0.46 | ||
| AF022375 | vascular endothelial growth factor (VEGF) | 0.40 | ||
| NM_013994 | discoidin domain receptor family, member 1 (DDR1) | 0.44 | ||
| NM_014000 | Vinculin (VCL) | 0.50 | ||
| Anti-inflammation | ||||
| AB025432 | delta sleep inducing peptide, immunoreactor (DSIPI) | 0.41 | 0.39 | |
| Cell growth, proliferation, differentiation, cell cycle | ||||
| NM_001946 | dual specificity phosphatase 6 (DUSP6) | 0.45 | ||
| NM_002165 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1) | 0.34 | ||
| NM_006286 | transcription factor Dp-2 (E2F dimerization partner 2) (TFDP2) | 0.37 | ||
| NM_002276 | keratin 19 (KRT19) | 0.35 | ||
| NM_001424 | epithelial membrane protein 2 (EMP2) | 0.42 | 0.44 | |
| NM_001431 | erythrocyte membrane protein band 4.1-like 2 (EPB41L2) | 0.42 | ||
| NM_005610 | retinoblastoma binding protein 4 (RBBP4) | 0.45 | 0.45 | |
| NM_006407 | cytoskeleton related vitamin A responsive protein (JWA) | 0.45 | ||
| AL122055 | cyclin-dependent kinase (CDC2-like) 11 (CDK11) | 0.45 | ||
| NM_016250 | NDRG family member 2 (NDRG2) | 0.46 | ||
| AF368463 | carboxypeptidase M (CPM) | 0.47 | 0.47 | |
| NM_005708 | glypican 6 (GPC6) | 0.49 | ||
| NM_006835 | cyclin I (CCNI) | 0.20 | ||
| AB023182 | serine/threonine kinase 38 like (STK38L) | 0.32 | 0.11 | |
| AF218029 | H3 histone, family 3B (H3.3B) (H3F3B) | 0.22 | ||
| NM_001431 | erythrocyte membrane protein band 4.1-like 2 (EPB41L2) | 0.25 | ||
| NM_006185 | nuclear mitotic apparatus protein 1 (NUMA1) | 0.36 | ||
| NM_001553 | insulin-like growth factor binding protein 7 (IGFBP7) | 0.37 | ||
| NM_001980 | Epimorphin (EPIM) | 0.38 | ||
| AK055976 | thymosin, beta 4, X-linked (TMSB4X) | 0.40 | ||
| NM_005778 | RNA binding motif protein 5 (RBM5) | 0.41 | ||
| NM_014399 | transmembrane 4 superfamily member 13 (TM4SF13) | 0.41 | ||
| NM_006791 | mortality factor 4 like 1 (MORF4L1) | 0.47 | ||
| Transcriptional regulation | ||||
| NM_001271 | chromodomain helicase DNA binding protein 2 (CHD2) | 0.38 | ||
| NM_003924 | paired-like homeobox 2b (PHOX2B) | 0.41 | 0.43 | |
| AJ420430 | general transcription factor IIIC, polypeptide 4, 90 kDa (GTF3C4) | 0.41 | ||
| NM_002938 | ring finger protein 4 (RNF4) | 0.44 | 0.28 | |
| D49835 | ras responsive element binding protein 1 (RREB1) | 0.49 | ||
| NM_002624 | prefoldin 5 (PFDN5) | 0.32 | ||
| NM_003418 | zinc finger protein 9 (a cellular retroviral nucleic acid binding protein) (ZNF9) | 0.34 | ||
| NM_031243 | heterogeneous nuclear ribonucleoprotein A2/B1 (HNRPA2B1) | 0.36 | ||
| NM_003151 | signal transducer and activator of transcription 4 (STAT4) | 0.38 | ||
| AB058726 | PHD finger protein 6 (PHF6) | 0.34 | 0.39 | |
| NM_002228 | v-jun sarcoma virus 17 oncogene homolog (avian) (JUN) | 0.40 | ||
| NM_003205 | transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) (TCF12) | 0.43 | ||
| NM_031314 | heterogeneous nuclear ribonucleoprotein C (C1/C2) (HNRPC) | 0.43 | ||
| NM_001300 | core promoter element binding protein (COPEB) | 0.45 | ||
| AL133574 | TEA domain family member 1 (SV40 transcriptional enhancer factor) (TEAD1) | 0.45 | ||
| AK027071 | transforming growth factor beta-stimulated protein TSC-22 (TSC22) | 0.46 | ||
| AJ420430 | general transcription factor IIIC, polypeptide 4, 90 kDa (GTF3C4) | 0.50 | ||
| Apoptosis, stress response | ||||
| NM_000581 | glutathione peroxidase 1 (GPX1) | 0.30 | ||
| NM_000041 | apolipoprotein E (APOE) | 0.36 | ||
| NM_004394 | death-associated protein (DAP) | 0.40 | ||
| NM_000851 | glutathione S-transferase M5 (GSTM5) | 0.45 | ||
| NM_021003 | protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform (PPM1A) | 0.48 | ||
| Energy generation or protein synthesis | ||||
| NM_020041 | solute carrier family 2 (facilitated glucose transporter), member 9 (SLC2A9) | 0.42 | ||
| AL136693 | cytochrome b reductase 1 (CYBRD1) | 0.42 | ||
| NM_002164 | indoleamine-pyrrole 2,3 dioxygenase (INDO) | 0.44 | 0.29 | |
| AF113701 | ribosomal protein L22 (RPL22) | 0.49 | ||
| NM_021194 | solute carrier family 30 (zinc transporter), member 1 (SLC30A1) | 0.49 | ||
| NM_000971 | ribosomal protein L7 (RPL7) | 0.22 | ||
| NM_015994 | ATPase, H+ transporting, lysosomal 34 kDa, V1 subunit D (ATP6V1D) | 0.31 | ||
| NM_001010 | ribosomal protein S6 (RPS6) | 0.32 | ||
| NM_001867 | cytochrome c oxidase subunit VIIc (COX7C) | 0.35 | ||
| NM_020041 | solute carrier family 2 (facilitated glucose transporter), member 9 (SLC2A9) | 0.38 | ||
| NM_001967 | eukaryotic translation initiation factor 4A, isoform 2 (EIF4A2) | 0.42 | ||
| NM_001961 | eukaryotic translation elongation factor 2 (EEF2) | 0.43 | ||
| NM_001418 | eukaryotic translation initiation factor 4 gamma, 2 (EIF4G2) | 0.43 | ||
| NM_003753 | eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67 kDa (EIF3S7) | 0.43 | ||
| NM_001460 | flavin containing monooxygenase 2 (FMO2) | 0.45 | ||
| AK057575 | solute carrier family 25 (mitochondrial carrier* phosphate carrier), member 3 (SLC25A3) | 0.46 | ||
| AK057299 | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (DLAT) | 0.48 | ||
| NM_016091 | eukaryotic translation initiation factor 3, subunit 6 interacting protein (EIF3S6IP) | 0.50 | ||
| Cardiovascular calcifications | ||||
| NM_000900 | matrix Gla protein (MGP) | 0.25 | 0.19 | |
| Protein transport | ||||
| NM_001282 | adaptor-related protein complex 2, beta 1 subunit (AP2B1) | 0.38 | ||
| NM_004914 | RAB36, member RAS oncogene family (RAB36) | 0.40 | ||
| NM_002865 | RAB2, member RAS oncogene family (RAB2) | 0.34 | ||
| AK057157 | RAB6A, member RAS oncogene family (RAB6A) | 0.25 | ||
| AK000757 | sortilin 1 (SORT1) | 0.47 | ||